Enclomiphene Citrate


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Enclomiphene is a selective estrogen receptor antagonist, antagonizing the estrogen receptors in the pituitary gland, disrupting the negative feedback loop by estrogen towards the hypothalamic-pituitary-gonadal axis, ultimately resulting in an increase in gonadotropin secretion.


In men with secondary hypogonadotropic hypogonadism, this improves testosterone levels and sperm motility. Men with secondary hypogonadotropic hypogonadism have abnormally low testosterone levels due to low-normal levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH). The biological role of these hormones is to stimulate the endogenous production of testosterone by the testes.

Common symptoms of secondary hypogonadotropic hypogonadism include low libido, energy, and mood. In addition, men with low testosterone may experience osteoporosis, an increase in visceral fat, and the regression of secondary sexual characteristics.[13] Enclomiphene stimulates the endogenous production of testosterone. It works differently from traditional testosterone replacement therapy, which replaces testosterone using an exogenous source.

In addition, research has uncovered that enclomiphene increases total and free testosterone levels without increasing dihydrotestosterone disproportionately, suggesting that it “normalizes endogenous testosterone production pathways and restores normal testosterone levels in men with secondary hypogonadism.


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